Diagnosis, Treatment & Prognosis
Stevens-Johnson Syndrome
Diagnosis
The diagnosis of SJS is primarily based on the appearance of the skin lesions and their typical symmetrical distribution, especially if known risk factors are present. Nikolsy's sign, also known as scalded skin syndrome maybe also be present, which presents as the top layers of skin slipping off the lower layers with even slight pressure or mild rubbing.A biopsy of the lesions and examination under a microscope will confirm Erythema Multiforme by indicating tissue death and the presence of antibody deposits. A skin biopsy may is also helpful in distinguishing SJS from a similar blistering condition known as pemphigus or pemphigus vulgaris.
Treatment
(Please note, the following section is for informational purposes only and is not intended as medical advice. If SJS is suspected, see your health care professional immediately, on an emergency basis, and report any drug reactions to the FDA.)
The first step in treatment of Stevens-Johnson Sydrome from an adverse drug reaction is to immediately stop taking the suspected drug.
Treatment of the milder forms of the disease often includes:
- Cool, moist compresses for the skin
- Antihistimines to control itching
- Topical anesthetics for the mouth to ease discomfort
- Acetaminophen for fever and pain
More severe forms of Stevens-Johnson Syndrome, including TEN often include these treatments:
- Hospitalization
- Treatment in an intensive care or burn unit
- Corticosteroids for inflammation
- Antibiotics to control infection
- IV liquids to control deyhydration and loss of body fluids
- Isolation to prevent any secondary skin infections
- Skin grafts for the most severe cases>
- IVIG Treatment (immunoglobulin) has been successful in treating some SJS patients. It has shortened the course and limited side effects IF it is started during the beginning stage of SJS Read more sjssupport.org/pdf/brett.pdf
Prognosis
The prognosis and lasting effects of Stevens-Johnson Syndrome vary significantly depending on the individual, the form of the disease, and the extent of involvement of skin and mucosa. Milder forms usually indicate recovery in a month or two, but the condition may reoccur. The more severe forms of the disease can result in disfiguring scarring, impairment or loss of vision, and secondary infections including systemic sepsis. In the case of the TEN form of Stevens-Johnson Syndrome, death results in about one-third of cases. SJS is a very serious conditon and should be treated as an emergency situation at first onset. The disease can have life altering consequences for those who survive it, and many do not survive.
If you or a loved one has been afflicted with Stevens-Johnson Syndrome, please e-mail or call us today and we will evaluate your Stevens-Johnson claim for free.
The law firm of Levin, Papantonio, Thomas, Mitchell, Echsner & Proctor, P.A. is nationally recognized as the fourth-winningest law firm in the United States. Our attorneys specialize in product liability and drug litigation cases.